NuaryKEYWORDS Influenza; Cytotoxicity; SRB assay; MDCK cells; H1N1; Conventional knowledgeAbstract Variations in antioxidant and anti-viral activities (against Influenza AP/R/8 (H1N1) virus) between the leaves and stem bark of selected medicinal plants have been studied. Malin Darby canine kidney (MDCK) cells were utilised for the viral infection as well as the antiviral activity of the extracts was studied making use of sulphorhodamine B (SRB) assay. The stem bark with the plants which includes Strychnos minor, Diotacanthus albiflorus, Strychnos nux-vomica and Chloroxylon swietenia showed larger flavonoid contents too as two,20 -azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) scavenging activity when compared with their leaves. In case of 1,1-diphenyl-2-picrylhydrazyl (DPPH) activity, the stem bark of S. nux-vomica and leaf extract of C. swietenia showed the highest activity. Primarily based on the IC50 values, the stem bark extracts of Cayratia pedata (20.five lg/mL) and S. minor (22.4 lg/mL) showed high antiviral activity. In the mean-time S. nux-vomica, C. swietenia and C. swietenia bark extracts showed cytotoxicity for the MDCK cells. When comparing the stem bark and leaves the content of gallic acid, ferulic acid, o-coumaric acid, total flavonoids (TFC) and total phenols (TPC) was higher in stem bark and therefore their anti-viral activity was higher. Further study based around the metabolites against H1N1 can reveal the potential of therapeutic compounds against the viral disease.2015 The Authors. Production and hosting by Elsevier B.V. on behalf of King Saud University. This really is an open access report under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).* Corresponding author. Tel.: +82 two 450 3740; fax: +82 two 2201 3738. E-mail address: [email protected] (D.H. Kim). 1 Authors have contributed equally. Peer evaluation under duty of King Saud University.1. Introduction Plants would be the significant supply of discoveries of novel therapeutic compounds due to the fact of their high secondary metabolite content. These metabolites is often classified into many groups for instance flavonoid, phenolic, alkaloids etc. Primarily based around the content and variety the metabolites influence the antioxidant activityProduction and hosting by Elsevierhttp://dx.2,5-Dibromo-4-fluoropyridine supplier doi.374791-02-3 structure org/10.PMID:25023702 1016/j.sjbs.2015.01.011 1319-562X 2015 The Authors. Production and hosting by Elsevier B.V. on behalf of King Saud University. This can be an open access post beneath the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).Leaf and stem bark extracts against H1N1 against a variety of ailments. Biosynthesis of secondary metabolites in plants is extremely regulated by environmental conditions (Mariya et al., 2003). South India is one of the significant resources for a plethora of diverse medicinal plants and is reported for standard use against various illnesses. Actually the origin and diversity of Siddha medicine which was followed and practiced by Siddhas was discovered to be proof for the diversity on the medicinal plant in South India. Even right now many individuals are utilizing plant sources for their main health-related desires not just in South India but around the globe (Goleniowski et al., 2006; Gurib-Fakim, 2006). Mainly because the valuable data on medicinal plants was passed on to children and mostly orally their medicinal properties have became scattered (Nadembega et al., 2011). From the small knowledge that we’ve concerning the makes use of of such plants for treating many diseases it is going to be achievable to garner information on.